Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pages: 51. Chapters: The Selfish Gene, Primer, Semiconservative replication, Nucleic acid nomenclature, Proliferating cell nuclear antigen, Retinoblastoma protein, Telomerase, Okazaki fragment, 29 DNA polymerase, DNA clamp, Control of chromosome duplication, XPB, Replication timing, Helicase, DNA-binding protein, Topoisomerase, DNA replication factor CDT1, Cdc6, DNA ligase, Taq polymerase, Prokaryotic DNA replication, Origin of replication, Eukaryotic DNA replication, Replication fork, DNA polymerase III holoenzyme, Loop-mediated isothermal amplification, Primase, Processivity, Pfu DNA polymerase, Eukaryotic DNA polymerase, Licensing factor, Klenow fragment, Minichromosome maintenance, PcrA, Repressor lexA, T7 DNA Helicase, Rolling circle replication, DnaN, Slipped strand mispairing, Tus, DnaA, T7 DNA polymerase, Single-strand binding protein, Proofreading, DnaC, DnaB helicase, Pre-replication complex, OriDB, Replicon, DnaQ, Theta structure, DnaG, DnaH, Prokaryotic DNA polymerase, Microcosm: E. coli and the New Science of Life, S-phase-promoting factor, DnaS, DnaX, DNA polymerase eta, DnaE, DnaI. Excerpt: Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase in eukaryotic cells. It achieves this processivity by encircling the DNA, thus creating a topological link to the genome. It is an example of a DNA clamp. The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been ...