An ancient fundamentalist organization has chosen to lash out against its enemies by conducting several attacks simultaneously across the globe. One of the assaults unleashes a deadly virus within the Pentagon. When the virus mutates beyond anything the terrorists expected, the nation's capital is plunged into a violent zombie outbreak that threatens to infect everyone in the region. A desperate attempt to stop the potential global epidemic backfires as the infected survive a brutal pre-emptive strike and continue to wreak havoc on the human population when they reemerge from the bowels of the ruined city. Meanwhile, Grayson Donnelly, a former Army officer who is stranded in the Midwest during the outbreak, is forced to fight for his life and for the survival of his adopted community while his fiance, Emory, is trapped in the Washington, D.C. quarantine zone. She struggles to come to terms with her own survival while living in a government-operated refugee camp just outside of the city. In a nation that is nearing anarchy as the terrorists' heinous scheme takes on a life of its own, the two of them must learn to adapt and do whatever is necessary in order to survive.