Dee Dee Ramone doesn't quite know what he's getting himself into when he and his wife Barbara move into the squalid Chelsea Hotel with their dog Banfield. He spends most of his time trying to score drugs and walking Banfield, with whom he can magically communicate. Meanwhile, he can't stand his neighbors and shies away from violence, but wishes everyone were six feet under. He also thinks that the room he's staying in is the very room where his old friend Sid Vicious stabbed Nancy Spungen, and begins having nightmares of Nancy emerging from the bathroom with a knife wound. After one of his nightmares, an evil force enters his hotel room and hurls him against a wall. Dee Dee also gets involved with the transvestite lover of one of his gay fellow addicts. When his wife finds out, the two fight it out and become seriously wounded. During all this, Dee Dee is tormented by the living and dead demons that plague the hotel, along with the ghosts of his old dead punk rock friends Sid Vicious, Johnny Thunders and Stiv Bators. And that's when the Devil himself decides to join the party...