A healthy young man suddenly loses his memory, making him unable to remember the events of each passing hour. Two patients diagnosed with Lyme disease improve after antibiotic treatment only to have their symptoms mysteriously return. A young woman lies dying in intensive care bleeding, jaundiced, incoherent and none of her doctors know what is killing her. Dr Lisa Sanders, whose hugely popular New York Times column inspired the hit TV show House, M.D., takes us to patients bedsides to witness the process of solving these and other diagnostic dilemmas, providing a first-hand account of the expertise and intuition that lead doctors to make the right decisions. An endlessly fascinating medical detective story, Diagnosis opens up as never before the finer workings of the human body, and celebrates the dedicated physicians who we may all someday need to trust with our lives.