Nat Cochran, a young Virginia adventurer teams up with Rees Marquette who is an old French Canadian trapper, and learns the ways of the mountain man in the 1800s. On their way west, they become guides to the Wyandot Indian nation in its effort to relocate west of the Mississippi River. The two later lend assistance to three mountain men who are trapped by a large number of Comanches who are in search of a mysterious phenomenon whom they believe to be a god. Exciting episodes with Comanches, Apaches, a cattle drive, and encounters with the Mexican officials in New Mexico challenge the survival skills of these two men and their friends before they finally settle in the Jicarilla Mountain area to establish a ranch.